Moved this thread to the FSX forum rather than General.
Can you verify that you're using the PilotEdge software shown here?
https://www.pilotedge.net/pages/downloa ... re-p3d-fsxIf you're using the much older software, it was not capable of recognizing USB button presses (you'd need to use FSUIPC to trigger the PTT on and off commands). As long as you're using the new software (shown above), you should be able to configure the PTT to be triggered by the USB button without any issue.